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Fig. 2. Ectopic `pre-neoplastic' cells resemble tumor cells. Cerebella were
isolated from wild-type mice (A-C) and patched+/–
mice (D-G) at 7 days (A,D), 3 weeks (B,E) 6 weeks (C,F) or 12 weeks (G) of
age. Tissues were paraffin wax-embedded, sectioned and stained with
Hematoxylin and Eosin. At 7 days of age, wild-type and patched mutant
cerebella are indistinguishable, with densely-packed GCPs on the surface
(arrowheads in A and D). Note the presence of ectopic cells on the outside of
the cerebellum in adult patched mutant mice (asterisks in E and F)
but not in wild-type mice (B,C). These cells are present in the majority of
patched mutants, and resemble tumor cells (asterisk in G) in terms of
size, morphology and location.
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