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Fig. 3. Pre-neoplastic cells express the granule cell lineage marker Math1. Cerebella from 7-day-old (A) and 6-week-old (B) Math1-GFP transgenic mice, and from 6-week-old (C,E) and 18-week-old (D) Math1-GFP/patched+/– mice, were photographed using a Leica MZFLIII microscope equipped with SPOT camera and software. Fluorescent and bright-field images were overlaid using Photoshop. (D) Entire brain, with cerebellum (including tumor) at bottom. Note the GFP-expressing (green) pre-neoplastic and tumor regions (C-E) in patched mutant mice.





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