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Fig. 3. Expression of Fgf8 and Shh in the urethral epithelium of
wild-type and Fgfr2-IIIb-/- embryos. (A,B) Fgf8
expression in the distal urethral epithelium of male wild-type (A) and
Fgfr2-IIIb-/- (B) genital tubercles at E13.5. (C,D)
Shh expression in the urethral epithelium of male wild-type (C) and
Fgfr2-IIIb-/- (D) genital tubercles. The Shh
domain bifurcates proximally in the Fgfr2-IIIb-/- mutant
(D), where the urethral plate has opened. (E,F) Transverse sections through
the distal genital tubercle of E15.5 wild-type embryo, showing histological
organization (E) and Shh expression (F) in urethral epithelium
(boxed). (G,H) Transverse sections through the distal genital tubercle of
E15.5 Fgfr2-IIIb-/- mutant embryo reveal the lack of a
histologically distinct urethral epithelium (G) and the absence of
Shh expression (H).
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