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Fig. 7. Dilated cardiomyopathy in adult Tbx20^lacZ/+ and Tbx20^lacZ/+/Nkx2-5^lacZ/+ mice. (A) Expression of LacZ in adult Tbx20^lacZ/+ and Nkx2-5^lacZ/+ hearts. (B) Dilated right ventricle in Tbx20^lacZ/+/Nkx2-5^lacZ/+ heart. (C-F) Transverse sections of a wild-type heart and one Tbx20^lacZ/+/Nkx2-5^lacZ/+ heart that showed right ventricular dilation (haemotoxylin and eosin staining). Arrows indicate fibrosis. (G) Northern analysis of stress and hypertophy markers in three mice of each genotype from the echocardiographic cohort. LV, left ventricle; RV, right ventricle; wt, wild type.

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