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Fig. 1. Expression of Tbx20 in mouse development. Tbx20 is
expressed in cardiac progenitors at E7.75 (A), including a medial domain of
cells corresponding to a similar domain (B) of expression of Nkx2-5
(red arrowheads). These medial domains are a part of the anterior heart field
(AHF), and overlap with expression of Isl1 (C). Sections of the
embryos shown in A-C are shown in A'-C'. Sections of embryos at
E8.5 are shown in A''-C''; arrowheads show overlapping Tbx20,
Nkx2-5 and Isl1 expression. (D-F) Dynamic expression of
Tbx20 at E10.5 (D-D''), E12.5 (E-E'') and E16.5
(F-F''). At E10.5 (D-D''), Tbx20 is expressed in the
myocardium and cushion of the outflow tract (ot), in the myocardium and
endocardium of the right ventricle (rv), and in the atria (la), with weaker
expression in the left ventricular (lv) myocardium. Asterisk indicates the
interventricular septum. Tbx20 is expressed most strongly in the
endocardial cushions (red asterisks) at E12.5 (E-E''); at E16.5
(F-F''), its expression is primarily confined to cushion derivatives such
as the pulmonary valve (pv) and the aortic valve (av). (G,H) Tbx20
expression in motoneurons (asterisk and ochre arrowhead) and dorsal aorta (red
arrowhead) is lost in Shh-/- embryos at E9.5. Whole mounts
are shown in G, while transverse sections are shown in H.
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