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Fig. 2. Sirenomelia in Tsg-/-;Bmp7-/- and
Tsg+/–;Bmp7-/- compound mutants. (A,B)
Comparison of a wild-type neonate with a
Tsg-/-;Bmp7-/- mutant displaying sirenomelia.
The mutant appears normal up to the level of the hindlimbs which are fused.
(C-F) Alcian Blue (cartilage) and Alizarin Red (bone) preparations of
wild-type and Tsg-/-;Bmp7-/- and
Tsg+/–;Bmp7-/- mutants. (C,D) Lateral
view of the posterior region of a wild-type and
Tsg-/-;Bmp7-/- skeleton. In the mutant, the
tail is shorter and has fewer vertebrae. The single hindlimb contains two
femurs (fe), two tibias (ti), a single foot and lacks both fibulae (fi). (E,F)
Ventral views of the hindlimbs and pelvic region of a wild-type and
Tsg+/–;Bmp7-/- neonate. The mutant
hindlimb is formed by the fusion of two hindlimbs at the level of the ischium
(is); two feet are present, fused at the level of the heel. Insets in D and F
show higher magnification views of the feet of
Tsg-/-;Bmp7-/- and
Tsg+/–;Bmp7-/- neonates, respectively.
Digits are indicated by numbers and digit duplications by letters. il, ilium;
is, ischium; p, pubic bone; ps, pubic symphysis.
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