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Fig. 1. A comparison of notochords. (A) At 24 hours post fertilisation (hpf), the
zebrafish notochord (red) occupies a considerable volume of the embryo. (B)
This is especially apparent in cross-section, where the area of the notochord
is nearly equal to that of the neural tube. (C) By contrast, in an embryonic
day (E) 9 mouse embryo, the notochord is proportionally smaller, (D) taking up
a cross-sectional area of only a fraction of the neural tube. (A) Lateral view
of live 24 hpf zebrafish embryo. (B) Trunk-level cross section of a 24 hpf
zebrafish embryo. (C) Three dimensional reconstruction of an E9 mouse. White
line indicates level of section shown in D, with notochord highlighted in red.
(C,D) Adapted, with permission, from the Edinburgh Mouse Atlas Project
(Baldock et al., 2001;
Brune et al., 1999).