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Fig. 4. Expression of anterior patterning markers in Ssdp1^hsk/hsk mutants. In situ hybridization showing gene expression in the anterior visceral endoderm (AVE) (A-D), anterior definitive endoderm (ADE) (E-H) and the prechordal plate (I-P) in wild-type and Ssdp1^hsk/hsk mutants. Wild-type (A) and mutant (B, n=5/5) expression of Lefty1; wild-type (C) and mutant (D, n=7/7) expression of Lim1; wild-type (E) and mutant (F, n=4/4) expression of Hhex; wild-type (G,I) and mutant (H, n=4/4; J, n=2/9) expression of Cerl; wild-type (K) and mutant (L, n=0/6) expression of Dkk1, wild type (M) and mutant (N, n=0/6) expression of Foxa2, and wild-type (O) and mutant (P, n=0/3) expression of Gsc. n, number of embryos expressing the gene/number of embryos analyzed. Broken lines in A-D and E-H indicate the AVE and ADE, respectively. Arrows in I-P indicate the prechordal plate. (Q-T) Sagittal section of wild-type (Q,S) and mutant (R,T) embryos stained with Hematoxylin and Eosin. Scale bars: in D, 100 µm for A-D; in H, 100 µm for E-H; in P, 200 µm for I-P; in R, 200 µm for Q,R; in T, 200 µm for S,T.

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