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Fig. 5. Head defects in Ssdp1^hsk/hsk mutants. In situ hybridization showing the expression of various regional markers in wild-type and Ssdp1^hsk/hsk embryos. Wild-type (A,E) and mutant Six3 expression (B, n=2/5; F, n=0/8); wild-type (C,G) and mutant (D, n=7/7; H, n=1/5) Otx2 expression; wild-type (I) and mutant (J, n=0/2) Pax6 expression; and wild-type (K) and mutant (L, n=2/3) En2 expression. (M,N) Fgf8 was expressed in the commissural plate (arrowhead) and MHB (black arrow) in wild-type embryos (M), while MHB expression in Ssdp1^hsk/hsk mutants was observed at the anterior tip (black arrow in N, n=6/10). Expression of Krox20 was unaffected (M,N, white arrows). (O,P) Wnt1 expression in the MHB (O; arrow) was observed at the anterior tip in some Ssdp1^hsk/hsk mutants (arrow in P, n=3/5). Scale bars: in D, 200 µm for A-D; in P, 400 µm for E-P.

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