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Fig. 6. Effects of Src42A[KR] (B1-B3), Src42A[WT] (C1-C3) or Src42A[YF] (D1-D3) on cell-shape and Arm/E-cad distribution at stage 13 and possible release of Src-overexpressing cells from amnioserosa and dorsal epidermis (E-Q). pnr-GAL4 was used as driver for forced expression of Src42A genes. Green, Src42A; magenta, E-cad or Arm. (A1,A2) Wild type. Anterior is leftwards and dorsal upwards. Unlike Src42A[KR] (B1-B3), Src42A[WT] and Src42A[YF] expression caused significant change in morphology and increased cytoplasmic Arm and E-cad signals (B1-D3). (E-G) Arrowheads indicate Src-overexpressing isolated cells in Src42A[YF] embryos. (H-K) Cll (red) and Fas3 (green) are markers for amnioserosa (Jagla et al., 2001) and epidermis, respectively. Blue, Src42A. Most Src-overexpressing isolated cells (arrowheads in I-K) exhibited Cll (H-J) or Fas3 (K). (L-Q) Src-overexpressing isolated cells were TUNEL-stained (magenta) at stage 16 (N, arrows in Q) but not stage 13 (L,M, arrowheads in O,P). Green, Src42A. Insets in Q show enlarged TUNEL-positive isolated cells.





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