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Fig. 4. Tlr suppresses Sog gain-of-function activities in vivo. (A) Injections of
sog mRNA in one of the ventral four-cell stage blastomeres of
Xenopus embryos induces secondary axis formation (red arrowheads) in
tadpoles shown at development stages 19 and 28. Co-injection of tld
and tlr inhibit Sog-mediated secondary axis formation. To ensure
equimolecular amounts of mRNA, we used 2 ng capped mRNA for sog and
tld and 4 ng for tlr, which had a transcript approximately
twice as long as tld because of the longer pro-peptide and UTR
sequences. (B) Wing phenotypes produced by ectopic expression of Sog and Tsg
are suppressed by addition of activated Tld (atld) (UAS-tld27) or
wild-type Tlr (tlr) (UAS-tlr3).
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