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First published online June 1, 2005

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Transcription factor codes for neural development

Temporal and spatial combinations or codes of transcription factors control many aspects of development. Now, on p. 2709, Helms and co-workers describe a code comprising bHLH transcription factors that controls the generation of early-born dorsal neuronal populations in mice. The dorsal spinal cord contains a diverse array of neurons that form the circuitry linking the sensory input from the periphery to spinal cord motoneurons and the brain. The researchers use fate mapping and genetic experiments to show that, while the bHLH transcription factor Mash1 is necessary and sufficient for the specification of dI3 and dI5 neurons, the number of these neurons that form depends on the activity of the bHLH transcription factor Ngn2. Thus, the researchers suggest, the balance of Mash1 and Ngn2 activity is pivotal in establishing the correct composition of neurons in the dorsal spinal cord.

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Related articles in Development:

Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons

Amy W. Helms, James Battiste, R. Michael Henke, Yuji Nakada, Nicolas Simplicio, Francois Guillemot, and Jane E. Johnson
Development 2005 132: 2709-2719. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?