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Fig. 3. Cardiac differentiation and patterning in Tbx20 mutant embryos.
Analysis of molecular markers shows that cardiac differentiation and AP
patterning of the heart tube occur normally in the Tbx20 mutant.
Expression of pan-cardiac markers by in situ hybridization analysis (A-D) and
ß-galactosidase activity staining of a lacZ reporter gene in the
Tbx20 locus (E,F) in E9.5 hearts of wild-type (A-F) and
Tbx20–/– embryos (A'-F'). In situ
hybridization analysis of markers for AP patterning (G-K') and
left-right asymmetry (L,L') at E8.5, in wild-type (G-L) and in
Tbx20–/– (G'-L') hearts. Views are
from the left lateral side (A,A',C,C',E,E') or from the
ventral side (B,B',D,D',F,F',G-L'), with anterior up
in all cases. Expression patterns are explained in the main text. Markers and
genotypes are indicated in the figure.
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