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Fig. 5. Mash1 inhibits Ngn1 but not Ngn2 expression in the dorsal
neural tube. Immunofluorescence (A,B,D,E) and in situ hybridization (G-J) on
transverse sections of E10.5 mouse neural tubes. (A-C) There is no change in
levels of Ngn2 between wild-type (A) and
Mash1–/– (B) embryos. (D-F) There is no change
in expression of Mash1 between wild-type (D) and
Ngn2–/– (E) embryos. (G-J) The dorsal domain
of Ngn1 is expanded in Mash1–/– (H, arrow) and
Mash1–/–;Ngn2–/– (J,
arrow) relative to wild-type (G) embryos. No change was detected in Ngn1 in
Ngn2–/– (I) embryos. Each panel is
representative of the phenotype seen in at least three sections from at least
three embryos. Scale bar: 50 µm in A,B,D,E; 225 µm in G,H.
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