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Fig. 9. Blockade of endogenous RA synthesis inhibits forebrain SVZ cell proliferation. (A,B) Coronal sections through the anterior SVZ show confocal images of BrdU immunostaining after treatment of mice with vehicle (Veh, A) or disulfiram (DS; B) daily from P7-10. A single BrdU injection was administered 6 hours after the first DS/Veh injection. DS treatment decreases SVZ BrdU labeling compared with Veh. Insets in A and B are high magnification images of PSA-NCAM (left panels) or merged PSA-NCAM/BrdU double immunolabeling (right panels) showing that most BrdU-positive cells (red) in the SVZ are PSA-NCAM-positive (green) neuroblasts. (C) Quantification of BrdU immunoreactivity in a fixed dorsolateral SVZ area shows decreased BrdU labeling in the SVZ of DS-treated mice compared with controls. **Denotes P<0.01. Scale bars: 50 µm for A,B; 20 µm for insets.





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