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Fig. 7. Model of transcriptional regulation of early SPCGs. Fkh and CrebA are
directly regulated by the Scr/Exd/Hth complex. Late expression of CrebA
requires Fkh and Fkh is autoregulated. The expression of most of the SPCGs is
greatly reduced in CrebA mutants at all embryonic stages, whereas
only late (beyond stage 13) expression of all tested SPCGs is affected by the
loss of fkh function. As late expression of the SPCGs was lower in
late fkh mutants than in CrebA mutants, we propose the
existence of another early transcription factor gene in SPCG regulation. As
with CrebA, late but not early expression of this putative transcription
factor would require Fkh.
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