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Fig. 4. Delta1 activates Notch signaling in neighboring epithelial cells. (A-C,C') pTP-1Venus was transfected into stage 29 PV and cultured for 3 hours. Venus expression and expression of Delta1 are adjacent. (C') A high-magnification view of boxed area in C. Outline of cell shapes is shown on the right. (D,E) Stage 28 PV were co-transfected with pTP-1Venus and Delta1 expression vector, and cultured for 12 hours after transfection. Reporter activity was not detected. (F-H) pTP-1Venus was first transfected into stage 28 PV, and Delta1 expression vector was subsequently transfected 10 hours after the first transfection. After an additional 14 hours of culture, the reporter activity and Delta1 expression were detected. Exogenous Delta1 induced activation of the reporter in neighboring cells. Scale bar: 100 µm.





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