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Fig. 2. Nephric duct epithelium- and metanephric mesenchyme-specific Cre reporter
analysis. lacZ staining of Hoxb7tg/+;
R26R+/– (A,C,E,G,I,K,M,O,Q,S,U,W) and
Rarb2tg/+; R26R+/–
(B,D,F,H,J,L,N,P,R,T,V,X) mice. (A,B) Whole-mount embryo at E9.5. (C,D)
Cross-section of mesonephric region at E9.5. (E,F) Whole-mount embryo at
E10.5. Hoxb7-Cre activity was also observed in the dorsal root
ganglia and spinal cord (Yu et al.
2002). (G,H) Anterior region of the nephric duct at E10.5. (I,J)
Posterior region of the nephric duct at E10.5. (K,L) Sagittal section around
the posterior nephric duct region at E10.5. (M,N) Dorsal view of the
urogenital system at E12.5. Mosaic Hoxb7-Cre and Rarb2-Cre
reporter activity was observed in the adrenal gland. (O,P) Cross-section of
the metanephros at E12.5. (Q,R) Cross-section of the posterior reproductive
tracts. Rarb2-Cre reporter activity was mosaic in the mesenchyme of
the posterior reproductive tracts. (S,T) Whole-mount urogenital system at
E14.5. (U,V) Tip of ureteric bud in the cortical region of the metanephros at
E14.5. (W,X) High magnification of the glomerulus at E14.5. a, adrenal; ca,
caudal mesonephros; cb, comma-shaped body; cd, collecting duct; cm, condensed
mesenchyme; cr, cranial mesonephros; cs, cortical (outer) stroma; dg, dorsal
root ganglia; ey, eye; fl, forelimb; gc, glomerular capillaries; gl,
glomerulus; gn, gubernaculum. gu, gut; hl, hindlimb; k, kidney (metanephros);
lpm, lateral plate mesoderm; md, Müllerian duct; mm, metanephric
mesenchyme; ms, medullary (inner) stroma; mt, mesonephric tubule; nd, nephric
duct; nm, nephric mesenchyme; np, nephron progenitor; nt, neural tube; ob,
outer layer of Bowman's capsule; ov, ovary; pa, pretubular aggregate; pc,
podocyte; sb, S-shaped body; tu, tubules of nephron; ub, ureteric bud; ur,
ureter; wd, Wolffian duct.
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