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Fig. 3. Urogenital abnormalities in tissue-specific knockout of Lim1 in the nephric duct epithelium or nephric mesenchyme. (A-C) Lim1 expression in the metanephros of tissue-specific Lim1 mutants at E12.5. Nephric duct epithelium-specific Lim1 knockout mice, Hoxb7Cre^tg/+; Lim1^lz/flox (B), and metanephric mesenchyme-specific Lim1 knockout mice, Rarb2Cre^tg/+; Lim1^lz/flox (C). Lim1^lz/flox (A) is shown for comparison. (D-F) Histological sections of A-C, respectively. (G-R) Phenotypes of the urogenital system of Lim1^lz/flox (G,J,M,P), Hoxb7Cre^tg/+; Lim1^lz/flox (H,K,N,Q) and Rarb2Cre^tg/+; Lim1^lz/flox (I,L,O,R) neonates. Males (G-L) and females (M-R). (G-I) Ventral view of the urogenital system in male neonates. (J-L) Lateral view of the testicular region of male neonates. Black arrows in K indicate residual tissue of male reproductive tracts. (M-O) Ventral view of the urogenital system in female neonates. (N) Black arrow indicates hydronephrosis and the black arrowhead hydroureter. (P-R) High magnification of the anterior female reproductive tract region. Black arrows in Q indicate residual tissue of the uterus. a, adrenal; ed, epididymis; ge, genitalia; k, kidney (metanephros); np, nephron progenitor; od, oviduct; ov, ovary; t, testis; ub, ureteric bud; ur, ureter; ut, uterus; vd, vas deferens.

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