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Fig. 4. Abnormal development of the reproductive tract in nephric duct epithelium-specific Lim1 knockout mutants. (A-F) Lim1-lacZ expression in Lim1^lz/+ (A,D), Lim1^lz/neo (B,E) and Hoxb7Cre^tg/+; Lim1^lz/flox (C,F) embryos at E9.5. (A-C) Lateral view of whole embryos. (D-F) Cross-sections of A-C, respectively. White arrows in B and E indicate disorganized Lim1-lacZ-positive cells in Lim1-null mutants, which form the epithelial tubule of the nephric duct in control (A,D) and Hoxb7Cre^tg/+; Lim1^lz/flox (C,F) mice. (G-R) Lim1-lacZ expression in developing urogenital organs of Lim1^lz/flox (G,I,K,M,O,Q) and Hoxb7Cre^tg/+; Lim1^lz/flox (H,J,L,N,P,R). (G-J) E11.5. (G,H) Lateral view of the urogenital system. (I,J) Ventral view of the mesonephros. White arrows in H and J indicate the degenerating nephric (Wolffian) duct. (K-N) E12.5. (K,L) Ventral view of the urogenital system. (M,N) Ventral view of the anterior mesonephros. Black arrowheads indicate the posterior end of the Müllerian duct; white arrow and arrowheads indicate gap in the Wolffian duct epithelium that inhibits or does not inhibit Müllerian duct elongation, respectively. (O,P) Ventral view of the left half of the urogenital system at E13.5. White arrow indicates gap in the Müllerian duct epithelium. (Q,R) Lateral view of the testis region at birth. White arrows indicate residual epithelium of the male reproductive tract. ed, epididymis; g, gonad; k, kidney (metanephros); lpm, lateral plate mesoderm; m, mesonephros; md, Müllerian duct; mt, mesonephric tubule; nd, nephric duct; nm, nephric mesenchyme; sm, somite; t, testis; ub, ureteric bud; vd, vas deferens; wd, Wolffian (nephric) duct.

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