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Fig. 5. Analysis of metanephros development in nephric duct epithelium- and
metanephric mesenchyme-specific Lim1 knockout mutants. Metanephros of
nephric duct epithelium-specific Lim1 knockout mice,
Hoxb7Cretg/+; Lim1lz/flox (B,F,J,N,R) and
metanephric mesenchyme-specific Lim1 knockout mice,
Rarb2Cretg/+; Lim1lz/flox (C,G,K,O,S).
Lim1lz/flox (A,E,I,M,Q),
Wnt4–/– (D,H) and
Wnt4–/–; Lim1lz/+ (L,P,T) mice are
shown for comparison. (A-P) Metanephros at birth, except for L and P (E14.5).
(A-D) Hematoxylin and Eosin stained coronal sections. (E-H) High magnification
of the cortical regions in A-D, respectively. (I-L) Ventral view of
Lim1-lacZ-stained whole-mount metanephros. (M-P) Section of cortical
region in I-L, respectively. White arrowheads in O indicate
Lim1-lacZ-positive cells in degenerating renal vesicles. (Q-T)
Lim1-lacZ stained whole-mount metanephros at E12.5. a, adrenal; cb,
comma-shaped body; cd. collecting duct; cm, condensed mesenchyme; gl,
glomerulus; m, medulla; np, nephron progenitor; pa, pretubular aggregate; rv,
renal vesicle; sb, S-shaped body; st, stalk; tu, tubules of the nephron; ub,
ureteric bud.
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