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Fig. 8. Chimera analysis of Lim1 functions in kidney development. Chimeric mice composed of wild-type and Lim1^+/+; Rosa26^tg/+ (A,C,E,G,I,L,O,Q) or Lim1^–/–; Rosa26^tg/+ (B,D,F,H,J,K,M,N,P,R,S,T) cells. (A,B) Cross-sections at E9.5. Dorsal is towards the top and ventral towards the bottom. (C-F) Sagittal sections of the mesonephros (C,D) and metanephros (E,F) regions at E10.5. Anterior is leftwards, posterior rightwards, dorsal is towards the top and ventral is towards the bottom. (G-T) Developing nephrons at E18.5. (G,H) Pretubular aggregate. (I-K) Renal vesicle. Early (J) and late (K) stages. Lim1^–/– cells are excluded in a subregion of the renal vesicle (white arrow in K). (L-N) Comma-shaped body. Early (M) and late (N) stages. White arrows indicate the invaginating epithelium of the first cleft. Lim1^–/– cells are also excluded from a part of the comma-shaped body at the opposite side of the epithelial invagination (white arrowhead in N). (O,P) S-shaped body. White arrow indicates invaginated epithelium originally formed; white arrowhead indicates newly formed invagination. (Q-T) Glomerulus (proximal regions of the developing nephron indicated by boxes in O and P). Early (R), middle (S) and late (Q,T) stages. White arrows indicate the developing podocyte where Lim1^–/– cells are excluded; white arrowheads indicate the outer epithelium of Bowman's capsule where Lim1^–/– cells can contribute. cb, comma-shaped body; cm, condensed mesenchyme; gc, glomerular capillaries; gu, gut; lpm, lateral plate mesoderm; mm, metanephric mesenchyme; mv, mesonephric vesicle; nd, nephric duct; nm, nephric mesenchyme; nt, neural tube; pa, pretubular aggregate; pc, podocyte; rv, renal vesicle; sb, S-shaped body; ub, ureteric bud.

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