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First published online June 8, 2005

Development 132, 1302e (2005)
© The Company of Biologists Limited
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In this issue

Unravelling the genetics of sex

Mammalian sex determination is a complex business. For example, the sex-determining region on the Y chromosome (Sry) is essential for male genital development, but mutations in other genes can also cause sex reversal. Bouma et al. now present a new model for testicular development in male XY mice (see p. 3045) in which the upregulation of Sox9 in Sertoli cell precursors - an essential event for testis development - depends on the expression of correct doses of Sry and Dax1 (an X-linked gene), and of one or more autosomal genes. The authors' genetic, histological and gene expression analyses show, for example, that Dax1, which encodes a nuclear receptor transcription factor, is essential for embryonic testis development in a mouse strain that is particularly susceptible to disturbances of testicular development. Elegant genetic studies also lead the authors to suggest that Wnt4 might be a sex determination modifier locus, called Tda1, that is present on chromosome 4.Go



Related articles in Development:

Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells
Gerrit J. Bouma, Kenneth H. Albrecht, Linda L. Washburn, Andrew K. Recknagel, Gary A. Churchill, and Eva M. Eicher
Development 2005 132: 3045-3054. [Abstract] [Full Text]  




This Article
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