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First published online June 8, 2005

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Unravelling the genetics of sex

Mammalian sex determination is a complex business. For example, the sex-determining region on the Y chromosome (Sry) is essential for male genital development, but mutations in other genes can also cause sex reversal. Bouma et al. now present a new model for testicular development in male XY mice (see p. 3045) in which the upregulation of Sox9 in Sertoli cell precursors - an essential event for testis development - depends on the expression of correct doses of Sry and Dax1 (an X-linked gene), and of one or more autosomal genes. The authors' genetic, histological and gene expression analyses show, for example, that Dax1, which encodes a nuclear receptor transcription factor, is essential for embryonic testis development in a mouse strain that is particularly susceptible to disturbances of testicular development. Elegant genetic studies also lead the authors to suggest that Wnt4 might be a sex determination modifier locus, called Tda1, that is present on chromosome 4.

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Related articles in Development:

Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells

Gerrit J. Bouma, Kenneth H. Albrecht, Linda L. Washburn, Andrew K. Recknagel, Gary A. Churchill, and Eva M. Eicher
Development 2005 132: 3045-3054. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?