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First published online June 8, 2005

Development 132, 1306e (2005)
© The Company of Biologists Limited
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In this issue

Pbx1: a master co-regulator of organogenesis?

In many organs, transcription factor networks drive cell fate specification, morphogenesis and growth during organogenesis. Now, on p. 3113, Brendolan et al. report that the same is true for the spleen and provide evidence that Pbx1 is a key co-regulator of spleen ontogeny. By analysing asplenic mice mutant for the transcription factors Pbx1, Hox11, Nkx3.2 and Pod1, the researchers discover that Pbx1 is required for splenic cell fate specification during early embryogenesis and for later progenitor cell proliferation. They show that a crucial function of Pbx1 in spleen development occurs via its genetic and transcriptional interaction with Hox11. And, although Nkx3.2 and Pod1 control spleen development through separate pathways, Pbx1 genetically regulates components of both pathways. Given that loss of Pbx1 causes multiple organogenesis defects, Pbx1 may be a central hierarchical co-regulator of the development of several organs.


Related articles in Development:

A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
Andrea Brendolan, Elisabetta Ferretti, Valentina Salsi, Kelvin Moses, Susan Quaggin, Francesco Blasi, Michael L. Cleary, and Licia Selleri
Development 2005 132: 3113-3126. [Abstract] [Full Text]  




This Article
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