|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 1. Mouse Hox genes and their early temporal and spatial colinearity of
expression. (A) The four Hox clusters (a to d). Hox genes with the same number
(1 to 13) are called paralogs. Three paralog groups are shown (2, 4 and 9) in
colour to illustrate the early temporal co-linearity of their expression, as
shown in B. (B) Mouse embryos at: embryonic day (E) 7.2, late streak (LS)
stage; E7.5, neural plate (NP) stage; and E7.7, head fold (HF) stage. (C) An
E10.5 embryo, showing the spatial co-linearity of Hox gene expression.
Hox2 paralogs begin to be expressed earlier, and Hox4 and
Hox9 paralogs progressively later, in the posterior part of the
primitive streak (ps, indicated by a grey line on the posterior side of the
embryos in B). At E10.5, the expression domains of the 3' genes extend
to more anterior positions than that of the more 5' genes. For each
gene, the expression boundary is more anterior in the nervous system than in
the mesoderm. mes, mesoderm; nt, neural tube. Actual widths of embryos at
widest point: LS, 0.26 mm; NP, 0.44 mm; HF, 0.60 mm; E10.5, 4.1 mm.
|
