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Fig. 3. Rostral progression of Hox expression through the primitive streak region. The rostrally extending expression domain (purple) of a Hox gene (from the middle of a Hox cluster) in the posterior region of an E7.7 presomitic mouse embryo (anterior is towards the top). This Hox expression domain encompasses the area where cells emerge from the primitive streak and from the axial stem cell zone (see black arrows). It also crosses the posterior region of the axis, which is undergoing morphogenesis. Extra-embryonic mesoderm is produced from the posterior levels of the streak. Lateral plate and paraxial mesoderm emerge from more anterior levels. The approximate position of the axial stem cells is shown (yellow). The descendants of these stem cells contribute to the extending paraxial mesoderm and neural plate (black arrows). The node produces axial mesoderm (notochord), endoderm and the ventral midline of the neural plate (not shown). Extra-embryonic mesoderm production is indicated for the sake of completeness, although it has stopped by this stage.





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