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Fig. 7. Histone marks and nuclear reorganisation during co-linear Hox activation.
Schematic representation of histone marks and changes in the subnuclear
position of Hox genes before (E6.5) or at the time of their first expression
[E7.5 for Hoxb1 (b1), E8.5 for Hoxb4 (b4) and E9.5 for
Hoxb9 (b9)]. The histone marks on histone H3, methylated lysine 4
(pink) and acetylated lysine 9 (purple), poise the genes for transcription
from the moment the first Hox gene of the cluster (Hoxb1) is
activated. Individual genes loop out of their chromatin territory (CT, grey
line) at the time of their expression. Figure modified, with permission, from
Chambeyron and Bickmore (Chambeyron and
Bickmore, 2004), incorporating data from Chambeyron et al.
(Chambeyron et al., 2005) and
Rastegar et al. (Rastegar et al.,
2004). The looping out of Hoxb4 is a personal
extrapolation of the data on Hoxb1 and Hoxb9.
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