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Fig. 4. Dispensable role of PKB{gamma} for body weight and glucose metabolism. (A) Body weights of male Pkb{gamma}+/+ (white bars) and Pkb{gamma}-/- (black bars) mice were measured at different points in time (n=5-8 animals per genotype). Error bars represent s.d. NB, newborn. (B) Blood glucose concentrations from random-fed (RF) and overnight fasted (ONF) mice (n=8; 6 months old; Pkb{gamma}+/+ white bars and Pkb{gamma}-/- black bars). Error bars represent s.d. (C) Insulin tolerance test. Animals (n=6; 6 months old; Pkb{gamma}+/+ white triangles and Pkb{gamma}-/- black circles) were fasted overnight and insulin (1 U/kg) was administered by intraperitoneal injection. (C) Glucose concentrations were determined at indicated time points from whole blood collected from tail veins. Values were normalized to the starting glucose concentration at the administration of insulin. Error bars represent s.d. (D) Glucose tolerance test. Animals (n=6; 5-6 months old; Pkb{gamma}+/+ white triangles and Pkb{gamma}-/- black circles) were fasted overnight and glucose (2 g/kg) was orally administered. Blood glucose concentrations were sampled at the indicated times. Values were normalized to the starting glucose concentration at the administration of glucose. Error bars represent s.d.





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