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Fig. 5. Reduced brain weight and size of Pkb{gamma} mutant mice. (A) Weight of freshly dissected brains of male Pkb{gamma}+/+ (white bars) and Pkb{gamma}-/- (black bars) mice were measured at different points in time (n=5-8 animals per genotype). *P<0.05. Error bars represent s.d. NB, newborn. (B) Cranial, (C) caudal and (D) lateral views of brains from adult Pkb{gamma} wild-type (left side) and knockout (right side) mice. Co, cortex; CE, cerebellum; OB, olfactory bulb; BS, brainstem; HY, hypothalamus. (E-J) Representative sections from T2- weighted 3D MRI data sets acquired in vivo from the brains of Pkb{gamma}+/+ (E,G,I) and Pkb{gamma}-/- mice (F,H,J) from Pkb{gamma}+/- matings in sagittal (E,F), horizontal (G,H) and coronal (I,J) orientation. CC, corpus callosum; AC, anterior commissure; PC, posterior commissure. Scale bar: 1 mm.





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