spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 1. Foxn1::dnFgfr2-IIIb transgenic mice develop abnormal hair coats. (A-D) All transgenic mouse lines show strong expression of dnFgfr2-IIIb, as demonstrated by non-radioactive in situ hybridisation. Nevertheless, transcript levels are significantly different, especially between line #53 and lines #42 and #8. The inset in B shows transgene expression in line #53 after extended staining whereas the inset in (A) shows endogenous gene expression of a corresponding wild-type section. The inset in D demonstrates the expression pattern of the endogenous Foxn1 gene, which is identical to that of the dnFgfr2-IIIb transgene under the control of a 30 kb Foxn1 promoter fragment (B-D). (E-H) Strong transgene expression causes a silky hair coat appearance. During early development of the pelage, it also appears to be less dense in transgenic mice when compared with their wild-type littermates; body skin is still visible at day 10 after birth (F). Scale bars: 100 µm.





Right arrow Return to article