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Fig. 2. The number of medulla columns is reduced in Foxn1::dnFgfr2-IIIb
transgenic mice. (A-C) A comparison of hair coat composition demonstrates that
transgenic mice still possess all four hair types present in wild-type
animals. The overall length and shape of hairs is shown at the top, whereas
the microscopic appearance of the hair shaft structure is shown at the bottom.
The length of hair shafts is not affected. In wild-type mice, the number of
medulla columns differs between single hairs of the awl and auchene type (A).
In the strong expressing lines #8 and #42 the number of medulla columns is
generally reduced to one (B). The number is reduced by one in guard, awl and
auchene hairs of line #53, preserving the heterogeneity of hair shaft
structures of awl and auchene hairs (C). a, awl hair; au, auchene hair; g,
guard hair; z, zigzag hair. (D,E) Histological analyses of hair follicles
reveal an abnormal structure of the medulla. (F,G) The matrix and medulla of
wild-type and transgenic hair follicles do not contain TUNEL-positive cells.
(H,I) The proliferative compartment of hair follicles is largely unaffected by
transgene expression as demonstrated by Ki67 staining. In some wild-type
follicles, the zone of proliferating cells next to the dermal papilla appears
to extend more along the proximodistal axis than in more lateral parts of the
proliferative compartment (arrowheads). Such an extension has never been
observed in transgenic follicles. Scale bars: 50 µm.
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