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Fig. 3. Gsh2 is required to establish the boundary between the dI2 and dI3 progenitor domains. (A-D) Gsh1 expression in dI4 and dI5 progenitors (brackets) is largely unchanged in Gsh2^-/- embryos, although the Gsh1 domain shows a slight dorsal expansion when compared with wild-type (WT) embryos (arrow in D). (E,F) Ngn1 expression expands ventrally into the presumptive dI3 progenitor domain, as does Ngn2 expression (K,L), although to a lesser extent than Ngn1. (G,H) Mash1 expression is reduced in presumptive dI3 progenitors but is maintained in the adjacent dI4 and dI5 progenitor domains (brackets). (I,J) The expression of Dbx2 in dI6 progenitors is unchanged demonstrating that the boundary between the dI5 and dI6 progenitors is not altered in the Gsh2 mutant cord. The ventral boundary of Ngn1 at the dI5/dI6 border is also unchanged (E,F, see arrows). (M) Schematic summary of the changes in dorsal progenitor specification in the alar plate, showing a concomitant reduction of Mash1 expression and expansion of Ngn1 expression in the dI3 progenitor domain.

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