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Fig. 5. AER regression is delayed in Msx1-/-;
Msx2-/- double mutant embryos. Comparison of Fgf8
expression in control (A,C,E,G) and double mutant (B,D,F,H) embryos. (A-D) At
12.5 dpc, the AER has disappeared at the level of the interdigital spaces in
control embryos (A). In double-null embryos, it still appears continuous (B)
and thicker than normal (C,D). (E-H) At 14.5 dpc, the AER is normally absent
(E,G) but still observed at the digit tips of double-null embryos (F,H,
arrowheads). At this stage, the Fgf8 expression pattern confirms the
variability of the limb phenotypes ranging from oligodactyly (F) to
polydactyly (H). (A-D,G,H) Forelimbs. (E,F) Hindlimbs. (C,D) Anterior views of
A,B, respectively. Anterior is towards the right in A,B,E-H.
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