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Fig. 10. p27kip1 expression is disrupted in vivo with inhibition of TGFß signaling. Sections shown represent typical sections from the central-most region of the retina from animals receiving intraocular injections of either PBS/BSA, 250 ng EGF or 250 ng EGF + anti-TGFß cocktail. (A-C) PBS/BSA injected animals show distinct p27kip1 (red, A) labeling of CRALBP-positive (green, C) cell bodies in the inner nuclear layer (arrows). (D-F) In EGF-treated animals, p27kip1 staining (red, D) is still present in CRALBP+ (green, F) Müller glia, although slightly reduced, compared with control-treated animals. (G-I) p27kip1 (red, G) labeling is largely absent from the CRALBP+ (green, I) Müller glia after treatment with EGF and anti-TGFß cocktail combined. Scale bar: 50 µm.





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