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Fig. 6. Hdac1 functions upstream of the interaction between cyclin D1 and p27.
(A,B) cyclin D1 expression in wild-type (A) and add mutant
(B) retinas. Almost all retinal cells express cyclin D1 in
add mutants, while in wild-type retinas, cyclin D1
expression level decreases except in the CMZ (arrowheads). (C,D) p27b
expression in wild-type (C) and add mutant (D) retinas. p27b
expression is absent in the add mutant retinas. (E,F) add
mutant retinas expressing Myc-tagged Xenopus p27 labeled with
anti-Myc antibody (F, green) and anti-BrdU antibody (red). The introduction of
Xenopus p27 inhibits BrdU incorporation in the add mutant
retinas (arrowheads). (G,H) cmyc expression in wild-type (G) and
add mutant retinas (H). cmyc is expressed in the peripheral
CMZ (arrowheads) in wild-type retinas, while cmyc expression spreads
centrally in add mutant retinas (arrows/lines). cmyc
expression in wild-type retina treated with 1200 nM TSA (H, inset) spreads
over a large region.
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