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Fig. 6. Model for regulation of Sox9 expression in XY precursor somatic support cells. We hypothesize that upregulation of Sox9 is dependent on the correct expression levels of Sry, Dax1 and a gene (or genes) on distal Chr 4 referred to as Tda1 (testis-determining gene, autosomal 1). Perturbations in the expression level of any two of these three genes interferes with the upregulation of Sox9, and can result in the failure of the precursor somatic support cells to differentiate into Sertoli cells.





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