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Fig. 7. Epha3 expression in combined Hoxa13/Hoxd mutants. WISH
staining of right forelimbs from E12.5 littermates; anterior is to the left
and posterior to the right. (A) Wild-type Epha3 expression pattern at
E12.5. (B) Epha3 expression in transheterozygote littermate, where
one copy each of Hoxa13 and the Hoxd cluster are intact.
Epha3 expression is moderately gained similar to that seen when both
copies of the Hoxd cluster are deleted
(Fig. 5B). (C) The gain of
Epha3 expression spreads through much more of the autopod, distally
and posteriorly, when a single Hoxa13 is inactivated in combination
with a homozygous deletion of the Hoxd cluster. (D) Epha3 expression
in a double homozygote limb. Even though most of the autopod does not form in
this mutant, Epha3 expression is gained to the posterior extreme of
the limb bud (arrow). Because of the small size of the mutant limbs, it is
useful to compare with the expression in E11.5 embryos to illustrate the gain
of expression (as shown in Fig.
6B).
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