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Fig. 5. unc-54(RNAi) interacts with act-1,2,3(st15) and unc-60(su158) to generate highly arborized muscle arm termini. All animals shown contain the trIs30 transgene and express Mb::YFP in select BWMs, and DsRed2 in commissural motoneurons. Muscles 9 and 11 of the dorsal right quadrant are shown in the first column, the corresponding motoneurons in the middle column, and the merged image, with YFP false coloured green, is in the third column. Red arrows indicate arborized muscle arm termini, while green arrows indicate normal muscle arm termini, irrespective of the defects of the arm stalk. Red arrowheads indicate membrane extension defects, yellow arrowheads indicate errant flowing lateral muscle ends, while white arrowheads indicate discrete lateral muscle ends. In the second column, blue arrows indicate a normal dorsal cord, while an orange arrow indicates a defasciculated dorsal nerve cord. Note that the defasciculated nerve cords correlate with muscle arm termini arborization. Also note that in unc-60(su158); lev-11(RNAi) (G) and in unc-60(su158); unc-54(RNAi) (I) animals, the nerve cords are defasciculated, where none of the single mutants or RNAi-treatments result in defasciculated cords (C-E). Scale bars: 25 µm.

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