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Fig. 3. Analysis of Pbx1 and Nkx2.5 gene expression during early spleen organogenesis. In situ hybridization was performed on frozen sagittal sections of E12-12.5 embryonic upper abdominal organs. (A-F) Normal expression of Pbx1 within the developing splenic anlage of Hox11-/-, Pod1-/- and Nkx3.2-/- embryos. (G-L) Perturbed expression of Nkx2.5 in Pod1-/- and Pbx1-/- embryos. Nkx2.5 expression is unperturbed in the developing splenic anlage of Hox11-/- embryos (H), while it is absent in Pod1-/- (J) and Pbx1-/- (L) embryos, compared with their wild-type littermates (G,I,K). L, liver; Sp, spleen; St, stomach.





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