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Fig. 7. Pbx1-dependent genetic network and transcriptional pathway regulate spleen ontogeny. (A) Transverse section of abdominal organs schematically illustrates the location of the spleen primordium during vertebrate development. Adapted, with permission, from Sadler (Sadler, 1995). To the right, the Pbx1-Hox11 transcriptional hierarchy regulating spleen ontogeny is depicted, with the Pbx1-dependent pathway in red. The Nkx2.5 downstream pathway is illustrated with a broken arrow as the requirement for Nkx2.5, an early marker of splenic progenitor cells, has not yet been demonstrated in spleen development. (B) Within the Pbx1-Hox11 transcriptional pathway, Pbx1 directly regulates Hox11 in spleen progenitor cells and Hox11, in turn, regulates its own promoter together with Pbx1.





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