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Fig. 6. Nkx6 compound mutants do not show a block in terminal differentiation of pancreatic endocrine cells. Immunofluorescence detection of IAPP (A-D), ISL1 (E-H) and PAX6 (I-L) in pancreas from wild-type, Nkx6.2^-/-, Nkx6.1^-/- and Nkx6.1^-/-;Nkx6.2^-/- embryos at E18.5. The number of IAPP⁺, ISL1⁺ and PAX6⁺ cells was similar in wild type (A,E,I) and Nkx6.2^-/- (B,F,J) embryos, reduced in Nkx6.1^-/- (C,G,K) and further decreased in Nkx6.1^-/-;Nkx6.2^-/- embryos (D,H,L), reflecting the gradual loss of ${alpha}$ - and ß-cells in Nkx6 mutants. Scale bar: 50 µm.

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