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Fig. 1. Zygotic loss of FRK-1 blocks epidermal enclosure and elongation during
embryogenesis. Differential interference contrast images of
frk-1(RNAi) (A), mDf7 homozygous (D), and wild-type (G)
embryos are shown at approximately 8.5 hours post-fertilization.
frk-1(RNAi) and mDf7 embryos arrest without enclosing. The
epidermal cells on the surface of the embryo round up and appear to be
defective in cell adhesion. Epidermal cells do not migrate properly and become
clustered together on the dorsal side of the embryo, as revealed with the
nuclear marker LIN-26 (B,E,H). Apical junctions in the epidermis, revealed
with antibody MH27, constrict and cluster dorsally (C,F,I). Embryos, as shown
in this and subsequent figures, are 
50 µm along the anteroposterior
axis.
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