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Fig. 4. Quantification of rescue experiments with homozygous mDf7 embryos. Percent embryonic lethality (empty bars) and enclosure defective (filled bars) in progeny from mDf7 heterozygotes is shown. All mDf7 homozygous embryos (25% of the progeny for this fully recessive deficiency) fail to enclose and die. Both phenotypes are efficiently rescued with cosmid T04B2 or a fragment containing frk-1. The kinase-dead FRK-1(D308R) mutant, Mouse FerT, and elt-1p-driven frk-1 all rescue enclosure effectively and embryonic lethality partially. Rescue of both phenotypes apparently requires expression in the lateral seam cells, as expression of frk-1 from the elt-3 promoter does not rescue mDf7. More than 300 embryos were scored for each independent array assayed in the rescue experiments.

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