|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 6. Developmental stage-dependent Bergmann glia defects in Pten-null
animals. (A,A') Sagittal sections immunolabeled with anti-BLBP antibody
and revealed significant enlargement of the immature Bergmann glial fibers in
Pten mutant at P3 (A'). (B,B') Bergmann glial scaffold
defects in Pten mutants at P7. In control littermates, BLBP-positive
Bergmann glia aligned as a single layer next to Purkinje neurons, whereas many
Pten mutant Bergmann glia were localized within the deeper IGL region
(arrowheads, B'). (C,C') Bergmann glia prematurely transformed
into an astrocytic morphology (arrowhead); shown at P14 in the mutant
(C'). Some astrocytic Bergmann fibers still retained end-feet on the
pial surface. EGL, external granule layer; ML, molecular layer; IGL, internal
granule layer. Scale bars: 50 µm.
|
