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Fig. 4. Lipid accumulation in hepatocytes is impaired in LAP-tTA/TRE-VEGFR2T mice. (A,B) Oil Red O staining of liver sections reveals decreased hepatocellular lipids in mutant livers (B) when compared with littermate control livers (A). Samples are counterstained with Hematoxylin. (C,D) Infusion experiment with DiI-labeled remnant lipoproteins demonstrates the quick and efficient uptake and transportation of serum lipid by hepatocytes in control livers (C) but not in mutant livers (D). (E,F) Anti-APOE staining shows continuous APOE accumulation in the space of Disse of control livers (E), whereas, in the mutant livers, an area with little or disrupted APOE distribution is evident (F).





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