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Fig. 5. Electron microscopy of liver sections shows defects in SEC and hepatocyte
morphology. There is an abundance of lipid droplets (white arrowheads) in the
control (A), but not in mutant (B), livers. SEM of livers shows fewer
sinusoidal channels (white arrows) in the mutant (B). TEM of control (C,E) and
mutant (D,F) livers reveals abnormal hepatocyte morphology, reduced hepatocyte
microvilli projections (black arrows), and disrupted space of Disse (black
arrowheads) in the mutant livers. SEM shows that mutant SECs lack fenestrae
(H), whereas SECs in control livers are highly fenestrated (white arrowheads
in G). EC, endothelial cell; L, lipid; H, hepatocyte; N, neutrophil; Er,
erythrocyte; S, sinusoid.
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