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Fig. 4. Inflow tract and cardiac laterality defects in adult Carp-Lbh transgenic mice. (A,B) Posterior view of 3-month-old wild-type (wt) and transgenic (Tg) hearts. Note abnormal pulmonary venous return (black arrow) in the Tg. (C,D) Transverse Hematoxylin and Eosin-stained sections of the hearts shown in (A,B). Note the dilated atria and ectopic veins (arrowheads) in the Tg. (E,F) Anterior in situ view of 5-month-old wt and Tg hearts. Dextrocardia (white arrow) and dextroposition of the vasculature (asterisk) were observed in the Tg heart only. (G,H) Frontal Hematoxylin and Eosin-stained sections of the hearts shown in E,F, showing the rightward inclination of the apex in the Tg heart (black arrowhead). (I,J) Close-ups of left ventricular (lv) myocardium, revealing cardiomyocyte hypoplasia in mispositioned Tg heart. ao, aorta; la, left atrium; pa, pulmonary artery; ra, right atrium; rv, right ventricle.

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