|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 5. Cardiomegaly in postnatal day 15 (P15) Carp-Lbh transgenic mice.
Hearts of wild-type (wt; A,D,G) and transgenic (Tg; B,C,E,F,H,I) littermates
at P15. (A-C) Frontal Hematoxylin and Eosin-stained sections at the levels of
the atrioventricular valves. The Tg#1 heart is hyperplastic (B,E), whereas the
Tg#2 heart is hypoplastic (C,F). Double-headed arrow marks the thickness of
the intraventricular septum (IVS). lv, left ventricle; rv, right ventricle.
(D-F) Higher magnification of hearts shown in (A-C) with close-up on IVS. Note
reduced cardiomyocyte size and fusion in Tg#2 (F). (G-I) Adjacent histological
sections from wt and Tg hearts shown in A-F stained with an
anti-phospho-histone H3 antibody, demonstrating ventricular hyperproliferation
of Tg#1 (H). (J) Average numbers of positive cells in selected areas
(n=3) of the RV, IVS and LV myocardium on three different sections of
each genotype per 100 DAPI-positive cells are shown. *P=0.016 versus
wt.
|
