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Fig. 1. Reddened skin in mouse and rat pups treated with angiopoietin 1. (A-C)
Snouts of wild-type adult mice (A) are pale compared with the reddened snout
of the transgenic K14-ANG1 mouse (B), which overexpresses angiopoietin 1 in
the skin. Prolonged treatment (10 days) of normal adult mice with
ANG14FD protein (C) or Adeno-ANG1* adenovirus (not shown) does not
cause reddening. (D) Snouts of mouse pups treated for 7 days (beginning at P7)
with PBS or ANG14FD (200 µg ip). The snout (arrow), gums and
tongue of the pups treated with ANG14FD are markedly reddened
compared with the PBS-treated pup. (E,F) Snouts and ears of rat pups treated
for 7 days (beginning at P7) with PBS or ANG14FD. The snouts
(arrow), gums, tongues, paws (arrow) and ears (arrow) of rat pups treated with
ANG14FD (200 µg ip) are markedly reddened compared with
PBS-treated pups.
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