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First published online July 12, 2005

Development 132, 1501e (2005)
© The Company of Biologists Limited
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In this issue

Sperm and oocyte: a novel relationship buds


Intercellular communication between sperm and oocyte is essential for successful sexual reproduction. In nematodes, for example, the major sperm protein (MSP) acts as a hormone that promotes oocyte meiotic maturation. But how do sperm, which lack the usual protein secretion machinery, release this cytoskeletal protein? Kosinski and co-workers now reveal that in C. elegans, MSP is exported from sperm through a novel vesicle-budding mechanism (see p. 3357). Their results suggest that the localized assembly of MSP filaments in spermatozoa and spermatids drives the formation of plasma membrane protrusions on the cell body, which form vesicles with inner and outer membranes between which MSP is sandwiched. These vesicles then function as MSP time-release capsules. Because proteins with MSP domains are found in fungi, plants and animals, this unconventional protein export pathway might also function in other developmental situations.


Related articles in Development:

C. elegans sperm bud vesicles to deliver a meiotic maturation signal to distant oocytes
Mary Kosinski, Kent McDonald, Joel Schwartz, Ikuko Yamamoto, and David Greenstein
Development 2005 132: 3357-3369. [Abstract] [Full Text]  




This Article
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